ASHP
  • Program
  • Registration
  • ASHP Spotlight
  • Midyear Coverage
  • Awards and Events
  • ASHP Marketplace
  • Meeting Info
  • Previews
Topics
  • ASHP Spotlight
  • Midyear Coverage
  • Awards and Events
  • ASHP Marketplace
  • Meeting Info
  • Previews
Resources
  • Program
  • Registration
Facebook iconTwitter iconLinkedIn iconInstagram icon
December 6, 2022

Learn About Helicobacter pylori Treatment Options

Catch up on current and up-and-coming treatments for the often-unrecognized infection.


Denise Kelley
Denise Kelley

A 53-year-old man with a complex medical and medication history reports having episodes of nausea, vomiting, and abdominal pain for several weeks. What’s your treatment recommendation for the physician whose workup includes bloodwork to diagnose Helicobacter pylori infection while considering a possible endoscopy?

If you said serologic testing isn’t predictive for diagnosing H. pylori infection, but you can devise a treatment plan if the patient tests positive for infection by endoscopy or another acceptable method, you’re correct, said Denise Kelley, clinical pharmacy specialist in internal medicine for Ascension Seton in Austin, Texas.

Kelley opened the Dec. 6 Midyear Clinical Meeting & Exhibition session Revisiting the Story of H. Pylori: An Update on Managing Helicobacter Pylori Infection.

About a third of the U.S. population is estimated to harbor H. pylori in the digestive tract. Kelley said the reason pharmacists don’t encounter H. pylori more often in clinical practice is that many infections are asymptomatic. But untreated infections can lead to peptic ulcer disease, non-ulcer dyspepsia, gastric cancer, and mucosa-associated lymphoid tissue lymphoma.

For that reason, Kelley said, treating a diagnosed infection is better than leaving it unaddressed.

She said decisions about which medication regimen to use are complicated by a lack of solid effectiveness data and the need to base recommendations on antimicrobial resistance rates that may not be readily available.

Guidelines from the American College of Gastroenterology (ACG) describe several treatment options, including clarithromycin triple therapy, bismuth quadruple therapy, and concomitant therapy consisting of a proton pump inhibitor (PPI), clarithromycin, amoxicillin, and metronidazole.

For Kelley’s case patient, who tested positive for H. pylori infection by endoscopic biopsy, the treatment workup required an evaluation of past exposure to macrolides, penicillin allergy history, and local resistance rates to clarithromycin.

Kelley noted that clarithromycin triple therapy (clarithromycin, amoxicillin, and a PPI) was an ACG first-line regimen for H. pylori infection in 2007. But ACG now recommends the regimen only when local rates of H. pylori clarithromycin resistance are less than 15%.

Kelley said most clinicians probably don’t know their local resistance rate. Limited available surveillance data — including data in Texas — indicate that local rates often exceed 15%, making clarithromycin triple therapy a poor option for the case patient. The patient also reported taking azithromycin twice during the past year, which raised a red flag about macrolide exposure.

An informal poll of the Midyear session audience found most in favor of AGC’s current first-line recommendation of quadruple therapy with bismuth, tetracycline, metronidazole, and a PPI for the case patient.

Kelley agreed that the regimen “is probably the best choice” for the patient.

If clinicians want to make elimination of H. pylori infection the therapeutic goal, newer options — also with limited data — are also available, said session speaker Emmeline Tran, assistant professor at the Medical University of South Carolina. The main benefit of these treatments is that they may be better than traditional therapy at eradicating the infection.

“We want to try to get to a 90% eradication rate,” Tran said. “We haven’t really been able to get that with our past regimens.”

Novel treatment strategies include fluoroquinolone- and rifabutin-based therapy and high-dose regimens consisting of amoxicillin with dexlansoprazole or esomeprazole, Tran said. She said studies show eradication rates in the 90% range for regimens consisting of levofloxacin/omeprazole/nitazoxanide/doxycycline or rifabutin/amoxicillin/omeprazole.

Additional novel options include upping the PPI or metronidazole dosage in regimens that use those medications, increasing the duration of treatment, and adding probiotics to the regimen, Tran noted.

A final audience poll suggested the group isn’t yet ready to consider novel H. pylori treatments, preferring instead to recommend bismuth quadruple therapy for the case patient.

Tran indicated that progress toward better regimens for H. pylori treatment may be limited in part because clinicians don’t seem to view the illness the way they do other infectious diseases. An audience poll revealed that attendees’ clinical practice sites do not perform H. pylori susceptibility testing — a standard practice for the management of many infectious diseases.

“We just haven’t gotten there quite yet” for H. pylori, Tran said.

Featured Stories
Geospatial Tools Offer Fresh Perspective on Patient Care
Sponsored by ASHP
Geospatial Tools Offer Fresh Perspective on Patient Care
ASHP announces new Leadership Center and Membership Group
Sponsored by ASHP
ASHP announces new Leadership Center and Membership Group
More Content
Photo of doctors in lab coats jumping in the air
Midyear Coverage
Survey Finds High Burnout Among Pharmacists, Support for Workplace Wellness Efforts
November 29, 2022
From left: Julie Groppi, Tera Moore, Addison Ragan, Kristina Butler
Midyear Coverage
Telehealth Is the Future of Clinical Pharmacy Practice
December 7, 2022
Clockwise from bottom left: Rebecca Leon, Cynthia S. Valle-Oseguera, Shirley Wong
Midyear Coverage
Culturally Effective Care Reduces Health Disparities
December 7, 2022
Grabenstein
Midyear Coverage
New Vaccines Continue to Face the Wall of Public Opinion
December 7, 2022
Jeannell Mansur
Midyear Coverage
New Processes, Standards and Interpretations Coming from the Joint Commission
December 7, 2022
Christopher Farrell
Midyear Coverage
Improvements in COVID-19 Diagnostics Offer New Choices
December 7, 2022
Toyin Tofade (right) confers with poster presenter Yuh Lin (center)
Midyear Coverage
International Pharmacists Celebrate at the Midyear
December 7, 2022
Patricia Keinle
Midyear Coverage
Get Familiar Now With the Revisions to USP (797)
December 7, 2022
Students working on laptop computers with the text reading Educational Programming
Midyear Coverage
Join Us Wednesday Morning to Ramp Up Your Learning With the New Pharmacy Power Hour
November 21, 2022
Venessa Goodnow
Midyear Coverage
Mpox Focus Shifts to Prevention
December 6, 2022
Jahred Washington
Midyear Coverage
Health Systems Handle Changes to 340B Program
December 6, 2022
Lalita Prasad-Reddy
Midyear Coverage
'We Are All the Human Race'
December 6, 2022
ASHP
Facebook iconTwitter iconLinkedIn iconInstagram icon
© 2023 Ascend Media. All rights reserved.